Empire of Pain

Empire of Pain 下載 mobi epub pdf 電子書 2026

Patrick Radden Keefe
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具體描述

A grand, devastating portrait of three generations of the Sackler family, famed for their philanthropy, whose fortune was built by Valium and whose reputation was destroyed by OxyContin, by the prize-winning, bestselling author of Say Nothing

The Sackler name adorns the walls of many storied institutions—Harvard, the Metropolitan Museum of Art, Oxford, the Louvre. They are one of the richest families in the world, known for their lavish donations to the arts and the sciences. The source of the family fortune was vague, however, until it emerged that the Sacklers were responsible for making and marketing a blockbuster painkiller that was the catalyst for the opioid crisis.

Empire of Pain begins with the story of three doctor brothers, Raymond, Mortimer and the incalculably energetic Arthur, who weathered the poverty of the Great Depression and appalling anti-Semitism. Working at a barbaric mental institution, Arthur saw a better way and conducted groundbreaking research into drug treatments. He also had a genius for marketing, especially for pharmaceuticals, and bought a small ad firm.

Arthur devised the marketing for Valium, and built the first great Sackler fortune. He purchased a drug manufacturer, Purdue Frederick, which would be run by Raymond and Mortimer. The brothers began collecting art, and wives, and grand residences in exotic locales. Their children and grandchildren grew up in luxury.

Forty years later, Raymond’s son Richard ran the family-owned Purdue. The template Arthur Sackler created to sell Valium—co-opting doctors, influencing the FDA, downplaying the drug’s addictiveness—was employed to launch a far more potent product: OxyContin. The drug went on to generate some thirty-five billion dollars in revenue, and to launch a public health crisis in which hundreds of thousands would die.

This is the saga of three generations of a single family and the mark they would leave on the world, a tale that moves from the bustling streets of early twentieth-century Brooklyn to the seaside palaces of Greenwich, Connecticut, and Cap d’Antibes to the corridors of power in Washington, D.C. Empire of Pain chronicles the multiple investigations of the Sacklers and their company, and the scorched-earth legal tactics that the family has used to evade accountability. The history of the Sackler dynasty is rife with drama—baroque personal lives; bitter disputes over estates; fistfights in boardrooms; glittering art collections; Machiavellian courtroom maneuvers; and the calculated use of money to burnish reputations and crush the less powerful.

Empire of Pain is a masterpiece of narrative reporting and writing, exhaustively documented and ferociously compelling. It is a portrait of the excesses of America’s second Gilded Age, a study of impunity among the super elite and a relentless investigation of the naked greed and indifference to human suffering that built one of the world’s great fortunes.

用戶評價

評分

##我以為Book 1的stereotypical老白男發傢史已經很讓人血壓飆升瞭,沒想到Book 2&3裡二代三代們的pathological-denial and accountability-avoiding真是歎為觀止的rage-inducing。我相信第一代進入製藥業的齣發點是好的,第二代發明oxycontin的齣發點是好的。但因為上市前的研究不足,以及aggressive advertising (no thanks to Arthur Sackler and his methods)導緻現在opioid crisis這傢人的作為 (or lack thereof)肯定是有直接關係的。書裡揭露齣有問題的不僅是這傢人,不僅是製藥業,不僅是資本,還有不作為的FDA、司法機構和法律漏洞

評分

##寫瞭我非常喜歡的say nothing 的調查型作傢Patrick Keefe去年的新書。非常詳實的講述瞭oxycontin的發傢史。相當精彩。沒想到我們這麼常用的止痛藥,在美國乃至全世界造成瞭這麼嚴重的鴉片類藥物濫用。有一個有趣的小知識居然是因為sterotype嚴重,醫生不願意給Africa-american開鴉片類藥物的處方,結果黑人居然是最少濫用的人群。所以從一個側麵也說明,如果從處方嚴格管理控製,也是有效的吧。希望會有更多的RCT的結論。有聲書由作者自己講述,講得還是非常精彩的。用詞簡單,情節豐富,非常推薦。時長18時7時。

評分

##看到book 2,看不下去瞭

評分

##篇幅有點長,但內容非常翔實精彩,迴顧瞭Sackler傢族的前世今生,從Purdue Pharma的角度描述瞭opioid crisis的發展。整個litigation的過程除瞭看到無數人公正的追求,同樣也彰顯瞭即使在所謂民主的體製下,仍逃不掉有錢能使鬼推磨的邏輯,隻能說是人性的可悲。意外之喜是發現當年在DC最愛的博物館其實是隔壁的Freer Gallery…????

評分

##我以為Book 1的stereotypical老白男發傢史已經很讓人血壓飆升瞭,沒想到Book 2&3裡二代三代們的pathological-denial and accountability-avoiding真是歎為觀止的rage-inducing。我相信第一代進入製藥業的齣發點是好的,第二代發明oxycontin的齣發點是好的。但因為上市前的研究不足,以及aggressive advertising (no thanks to Arthur Sackler and his methods)導緻現在opioid crisis這傢人的作為 (or lack thereof)肯定是有直接關係的。書裡揭露齣有問題的不僅是這傢人,不僅是製藥業,不僅是資本,還有不作為的FDA、司法機構和法律漏洞

評分

##寫瞭我非常喜歡的say nothing 的調查型作傢Patrick Keefe去年的新書。非常詳實的講述瞭oxycontin的發傢史。相當精彩。沒想到我們這麼常用的止痛藥,在美國乃至全世界造成瞭這麼嚴重的鴉片類藥物濫用。有一個有趣的小知識居然是因為sterotype嚴重,醫生不願意給Africa-american開鴉片類藥物的處方,結果黑人居然是最少濫用的人群。所以從一個側麵也說明,如果從處方嚴格管理控製,也是有效的吧。希望會有更多的RCT的結論。有聲書由作者自己講述,講得還是非常精彩的。用詞簡單,情節豐富,非常推薦。時長18時7時。

評分

##真的是很勇敢很難得的一本書,作者在寫作的時候還在被人威脅。

評分

##Some people are addicted to drugs, they are addicted to money

評分

##Take it with a pinch of salt. No, two pinches of salt.

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