The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.
When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.
Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.
The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.
Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?
After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species.
##平平无奇 你好我好大家好
评分##科普的部分已经在其它书里见过了,传记的部分又不是很有意思。
评分##平平无奇 你好我好大家好
评分##其实应该叫The Code Breakers,除了Doudna and Charpentier, 作者对Zhang Feng的评价也很高,作者一直在强调对于基础科学研究的重要性,在十四五计划也有强调,期待各国能加大科研投入for a greater good
评分##作为对科技新闻有一定关注的读者,我是觉得传记大拿的这本新书略略有点水、有点散呀……可能书中纪事我多少有些了解,所以读来新鲜感不强。而厚厚近600页感觉有点四不像——既不是传记、也不是新闻调查;有点像在翻资料汇编,又有点像在刷公众号。 不过也不难看。最留下印象的几点: ➊用生物学词汇mosaic来形容人性的复杂多面向,a better description than grayscale; ➋第一次了解到biohackers(书中以Josiah Zayner为代表)这个群体。如何看待citizen science(民科)? ➌作者引用Michael Sandel教授关于“playing god”的论述; ➍D与C两位女科学家渐行渐远(不是闹翻)的友谊(研究合作与私交两个层面)。
评分##这本书的写法太闷了,吸引人的反而是那些争议角色,比如口无遮拦的沃森,或者死捧弟子的Eric Lander,其他角色都立不起来。好在crispr周围的抓马就算遇到这种笔触也丝毫没有减少八点档特质。伦理部分非常浅,有大段丝毫没有建设性的“上帝”“自然”讨论,这都什么年代了。在我看来社交网络还邪恶得要死呢,但人家已经在这里了,好好拆分和针对性解决吧。有朝一日我一定能等来有个性有文笔还不谈上帝的生物学家重写这段往事的
评分##除了学习科学知识 还借鉴得到成功科学家的品质 追求卓越注重合作然而又能严格管理自己的时间界限 生命科学的魅力 疫情初期紧锣密鼓的研究与疫苗开发 意外还有1984 vs. Brave New World这一对比重现 虽然有主POV CRISPR学术之争的叙述个人感觉尚且公正 希望能多收集一些行家线报实验室风云!
评分##除了学习科学知识 还借鉴得到成功科学家的品质 追求卓越注重合作然而又能严格管理自己的时间界限 生命科学的魅力 疫情初期紧锣密鼓的研究与疫苗开发 意外还有1984 vs. Brave New World这一对比重现 虽然有主POV CRISPR学术之争的叙述个人感觉尚且公正 希望能多收集一些行家线报实验室风云!
评分##很好的了解CRISP的科普
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