The Code Breaker

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Walter Isaacson
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具体描述

The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.

When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.

Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.

The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.

Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?

After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species.

用户评价

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##should be the code breakers. 一开始是抱着Bill Gates 推荐过所以想看,不得不说有点失望。但是看到Bill and Melinda Gates Foundation 资助了以后就也没那么意外了。

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##roadtrip上听完了有声书 比预计的更有意思更drama crispr出来的时候 很多报道podcast采访 biotech/genes也hype很久了 但都知道了些皮毛 这本书听完才觉得真的懂了些 science确实是很competitive的field 特别是这些lab类的 发文章cycle还算快 就真的是分秒必争 同事之间的合作和竞争关系微妙 好奇如果有本从boston角度来讲(vs. Berkeley)会是怎么个态度 Isaacson很是细节之王 多少年前的事情 估计当事人都记不清楚了 他能写细致至极 feminism贯穿了整本书 最后几章讲gene editing moral的有点散

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##科普的部分已经在其它书里见过了,传记的部分又不是很有意思。

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##"Great Inventions come from understanding basic science"

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##最多3.5星吧。与其说这是一本传记不如说是科普。然而作者写科普书的能力远不如其他专业学者。 关于基因编辑的道德问题作者花了很长的篇幅讨论,这个话题写几本书都可以,作者在这方面的理论知识显然还不够。道德问题谁都有权利发言,但写太多了看着很乏味。 零星的点:金字塔尖的竞争很激烈,人尖们犯过的错走过的弯路有借鉴意义,国外的前沿科学研究值得时刻跟进和关注。

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##很精彩的故事,高尖端的科技,科学家的争名夺利,关于道德的争论,都很有意思,不过感觉作者夹带私货略多

评分

##should be the code breakers. 一开始是抱着Bill Gates 推荐过所以想看,不得不说有点失望。但是看到Bill and Melinda Gates Foundation 资助了以后就也没那么意外了。

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##感觉看了一部宫斗剧?

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##很好的了解CRISP的科普

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