具体描述
The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.
When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.
Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.
The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.
Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?
After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species.
用户评价
##作为对科技新闻有一定关注的读者，我是觉得传记大拿的这本新书略略有点水、有点散呀……可能书中纪事我多少有些了解，所以读来新鲜感不强。而厚厚近600页感觉有点四不像——既不是传记、也不是新闻调查；有点像在翻资料汇编，又有点像在刷公众号。 不过也不难看。最留下印象的几点： ➊用生物学词汇mosaic来形容人性的复杂多面向，a better description than grayscale； ➋第一次了解到biohackers（书中以Josiah Zayner为代表）这个群体。如何看待citizen science（民科）？ ➌作者引用Michael Sandel教授关于“playing god”的论述； ➍D与C两位女科学家渐行渐远（不是闹翻）的友谊（研究合作与私交两个层面）。
评分##感觉看了一部宫斗剧？
评分##作为对科技新闻有一定关注的读者，我是觉得传记大拿的这本新书略略有点水、有点散呀……可能书中纪事我多少有些了解，所以读来新鲜感不强。而厚厚近600页感觉有点四不像——既不是传记、也不是新闻调查；有点像在翻资料汇编，又有点像在刷公众号。 不过也不难看。最留下印象的几点： ➊用生物学词汇mosaic来形容人性的复杂多面向，a better description than grayscale； ➋第一次了解到biohackers（书中以Josiah Zayner为代表）这个群体。如何看待citizen science（民科）？ ➌作者引用Michael Sandel教授关于“playing god”的论述； ➍D与C两位女科学家渐行渐远（不是闹翻）的友谊（研究合作与私交两个层面）。
评分##读了Emmanuelle Charpentier, Feng Zhang, &He jiankui, CRISPR, Gene editing historic records部分，作者写到science内容一笔带过，想了解详细内容自己去看文献，历史的部分讲述得比较精彩，不搞学术的人读了能看到研究进步发展时间线上科学家们的主导、参与、被遗忘、被放弃及存活的真实展现，good read
评分侦探小说一样，好看的简直停不下来，比前一步著作 达芬奇 好看的多，读达芬奇的时候 一直瞌睡。这本书简直停不下来。微积分的发现，大家争来争去，DNA结构的发现，大家争来争去，人类基因组计划，大家争来争去， crisper-cas9,大家争来争去。其实你发现没有，个人的贡献是有限的，没有谁，地球照样转。科学的发现和进步，是一个水到渠成，成千上万的人一步一步做出来的，个人的贡献往往被放大，而更多的人则被忽略。感觉Jennifer是一个很爱抢功劳的人，也许是中国人都zhangfeng有同情。不过她的合作者都疏远了她。鸡血的中国妈妈可以看看，美国也有尖子班，张峰也上补习班的，不过他上的是将荧光蛋白重组表达的相关工作。最不喜欢书里面的thought experiment, 是这本书最大的败笔
评分##A bit all over the place, but enligtening and informative. I'm learning things I didn't know and I thoroughly enjoyed the chapters where Issacson explored the ethical issues surrounding gene editing.
评分##很精彩的故事，高尖端的科技，科学家的争名夺利，关于道德的争论，都很有意思，不过感觉作者夹带私货略多
评分##真是一本一言难尽的书，有点不伦不类的。如果是个传记，那么这是我读过的最失败的传记了，读之前对女主充满了崇拜，读完了几乎好感全无，觉得她好胜心过强。这本书是开始介绍珍妮弗·道德纳的背景求学经历以及如何开始研究RNA ，然后变成了一本CRISPR 科普，又陆续介绍了一群对CRISPR有贡献的科学家，然后开始八卦道德纳和张的CRISPR 专利战，然后又开始讨论基因改造的道德性，然后聊了聊RNA和新冠，最后以得诺贝尔奖结束。其实与其写成传记，不如学成一部纪实文学，从各方面客观的去讲述基因改造的发展更好一些。 让我想八卦的地方是，作者至少在2019年就开始参加一些活动了，应该是在最迟2019就开始着手这本书，那么后来的诺贝尔和新冠只是巧合的话，作者也太好运了。
评分##其实应该叫The Code Breakers，除了Doudna and Charpentier, 作者对Zhang Feng的评价也很高，作者一直在强调对于基础科学研究的重要性，在十四五计划也有强调，期待各国能加大科研投入for a greater good
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