The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.
When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.
Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.
The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.
Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?
After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species.
##我並不很喜歡沃爾特.艾薩剋森,以前看過其喬布斯傳(中文),達芬奇傳(有聲書),總的來說,中規中矩。 然就本書而言,通過傳記故事的方式,學到很多生化知識,體驗象牙塔裏的科研生活,還是很有收獲。 最難忘懷的情節是他對Watson和其兒子的訪問,可惜太短,畢竟是枝節。 人物傳記,盡管是著名人物,要寫齣史詩感,張力十足也不容易。
評分##should be the code breakers. 一開始是抱著Bill Gates 推薦過所以想看,不得不說有點失望。但是看到Bill and Melinda Gates Foundation 資助瞭以後就也沒那麼意外瞭。
評分偵探小說一樣,好看的簡直停不下來,比前一步著作 達芬奇 好看的多,讀達芬奇的時候 一直瞌睡。這本書簡直停不下來。微積分的發現,大傢爭來爭去,DNA結構的發現,大傢爭來爭去,人類基因組計劃,大傢爭來爭去, crisper-cas9,大傢爭來爭去。其實你發現沒有,個人的貢獻是有限的,沒有誰,地球照樣轉。科學的發現和進步,是一個水到渠成,成韆上萬的人一步一步做齣來的,個人的貢獻往往被放大,而更多的人則被忽略。感覺Jennifer是一個很愛搶功勞的人,也許是中國人都zhangfeng有同情。不過她的閤作者都疏遠瞭她。雞血的中國媽媽可以看看,美國也有尖子班,張峰也上補習班的,不過他上的是將熒光蛋白重組錶達的相關工作。最不喜歡書裏麵的thought experiment, 是這本書最大的敗筆
評分##很精彩的故事,高尖端的科技,科學傢的爭名奪利,關於道德的爭論,都很有意思,不過感覺作者夾帶私貨略多
評分偵探小說一樣,好看的簡直停不下來,比前一步著作 達芬奇 好看的多,讀達芬奇的時候 一直瞌睡。這本書簡直停不下來。微積分的發現,大傢爭來爭去,DNA結構的發現,大傢爭來爭去,人類基因組計劃,大傢爭來爭去, crisper-cas9,大傢爭來爭去。其實你發現沒有,個人的貢獻是有限的,沒有誰,地球照樣轉。科學的發現和進步,是一個水到渠成,成韆上萬的人一步一步做齣來的,個人的貢獻往往被放大,而更多的人則被忽略。感覺Jennifer是一個很愛搶功勞的人,也許是中國人都zhangfeng有同情。不過她的閤作者都疏遠瞭她。雞血的中國媽媽可以看看,美國也有尖子班,張峰也上補習班的,不過他上的是將熒光蛋白重組錶達的相關工作。最不喜歡書裏麵的thought experiment, 是這本書最大的敗筆
評分##挺好看的,實效性很強,跟covid聯係很緊密。最喜歡看這種眾人拾柴火焰高,每個人的研究都為某個成功的發現奠定基石的故事。所以其實叫code breakers確實更閤適,很喜歡Doudna和Charpentier這種微妙的情感,既是閤作者又有點小競爭的感覺。中間有段講gene editing的好處和壞處覺得有點離題,好在後麵又拉迴來瞭
評分##讀瞭Emmanuelle Charpentier, Feng Zhang, &He jiankui, CRISPR, Gene editing historic records部分,作者寫到science內容一筆帶過,想瞭解詳細內容自己去看文獻,曆史的部分講述得比較精彩,不搞學術的人讀瞭能看到研究進步發展時間綫上科學傢們的主導、參與、被遺忘、被放棄及存活的真實展現,good read
評分##roadtrip上聽完瞭有聲書 比預計的更有意思更drama crispr齣來的時候 很多報道podcast采訪 biotech/genes也hype很久瞭 但都知道瞭些皮毛 這本書聽完纔覺得真的懂瞭些 science確實是很competitive的field 特彆是這些lab類的 發文章cycle還算快 就真的是分秒必爭 同事之間的閤作和競爭關係微妙 好奇如果有本從boston角度來講(vs. Berkeley)會是怎麼個態度 Isaacson很是細節之王 多少年前的事情 估計當事人都記不清楚瞭 他能寫細緻至極 feminism貫穿瞭整本書 最後幾章講gene editing moral的有點散
評分##這本書的寫法太悶瞭,吸引人的反而是那些爭議角色,比如口無遮攔的沃森,或者死捧弟子的Eric Lander,其他角色都立不起來。好在crispr周圍的抓馬就算遇到這種筆觸也絲毫沒有減少八點檔特質。倫理部分非常淺,有大段絲毫沒有建設性的“上帝”“自然”討論,這都什麼年代瞭。在我看來社交網絡還邪惡得要死呢,但人傢已經在這裏瞭,好好拆分和針對性解決吧。有朝一日我一定能等來有個性有文筆還不談上帝的生物學傢重寫這段往事的
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