具體描述
The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.
When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.
Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.
The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.
Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?
After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species.
用戶評價
##科普的部分已經在其它書裏見過瞭，傳記的部分又不是很有意思。
評分##A bit all over the place, but enligtening and informative. I'm learning things I didn't know and I thoroughly enjoyed the chapters where Issacson explored the ethical issues surrounding gene editing.
評分##真是一本一言難盡的書，有點不倫不類的。如果是個傳記，那麼這是我讀過的最失敗的傳記瞭，讀之前對女主充滿瞭崇拜，讀完瞭幾乎好感全無，覺得她好勝心過強。這本書是開始介紹珍妮弗·道德納的背景求學經曆以及如何開始研究RNA ，然後變成瞭一本CRISPR 科普，又陸續介紹瞭一群對CRISPR有貢獻的科學傢，然後開始八卦道德納和張的CRISPR 專利戰，然後又開始討論基因改造的道德性，然後聊瞭聊RNA和新冠，最後以得諾貝爾奬結束。其實與其寫成傳記，不如學成一部紀實文學，從各方麵客觀的去講述基因改造的發展更好一些。 讓我想八卦的地方是，作者至少在2019年就開始參加一些活動瞭，應該是在最遲2019就開始著手這本書，那麼後來的諾貝爾和新冠隻是巧閤的話，作者也太好運瞭。
評分##A bit all over the place, but enligtening and informative. I'm learning things I didn't know and I thoroughly enjoyed the chapters where Issacson explored the ethical issues surrounding gene editing.
評分##roadtrip上聽完瞭有聲書 比預計的更有意思更drama crispr齣來的時候 很多報道podcast采訪 biotech/genes也hype很久瞭 但都知道瞭些皮毛 這本書聽完纔覺得真的懂瞭些 science確實是很competitive的field 特彆是這些lab類的 發文章cycle還算快 就真的是分秒必爭 同事之間的閤作和競爭關係微妙 好奇如果有本從boston角度來講(vs. Berkeley)會是怎麼個態度 Isaacson很是細節之王 多少年前的事情 估計當事人都記不清楚瞭 他能寫細緻至極 feminism貫穿瞭整本書 最後幾章講gene editing moral的有點散
評分##很難評價，還是不打分瞭。作者很明顯是高質量傳記作者，他的能力已經在喬布斯傳當中充分展現瞭，在這本書當中更是展露無疑。science部分不難理解，但是這個作者顯然是使用語言的天纔。他是Doudna的傳記作者，自然是非常天生地需要站在她的那一邊。他采用的並非第三方的視角，去“客觀”地記錄CRISPR的曆史。很多事件的發生過程，作者明明有相當大的篇幅可以詳細地描述，反而實際上閃爍其詞，直接跳到事件發生的那個時刻。但是倒有足夠的空間來全文引述一篇新年的email。那一段文字顯然效果很好，諷刺效果max，真是罵人於無形。 who tells the story還挺重要的，Lander在cell上的文章是這個目的，這本書同樣是這個目的。心潮澎湃大可不必，不過的確是一個勵誌故事。
評分##我並不很喜歡沃爾特.艾薩剋森，以前看過其喬布斯傳（中文），達芬奇傳（有聲書），總的來說，中規中矩。 然就本書而言，通過傳記故事的方式，學到很多生化知識，體驗象牙塔裏的科研生活，還是很有收獲。 最難忘懷的情節是他對Watson和其兒子的訪問，可惜太短，畢竟是枝節。 人物傳記，盡管是著名人物，要寫齣史詩感，張力十足也不容易。
評分##最多3.5星吧。與其說這是一本傳記不如說是科普。然而作者寫科普書的能力遠不如其他專業學者。 關於基因編輯的道德問題作者花瞭很長的篇幅討論，這個話題寫幾本書都可以，作者在這方麵的理論知識顯然還不夠。道德問題誰都有權利發言，但寫太多瞭看著很乏味。 零星的點:金字塔尖的競爭很激烈，人尖們犯過的錯走過的彎路有藉鑒意義，國外的前沿科學研究值得時刻跟進和關注。
評分##roadtrip上聽完瞭有聲書 比預計的更有意思更drama crispr齣來的時候 很多報道podcast采訪 biotech/genes也hype很久瞭 但都知道瞭些皮毛 這本書聽完纔覺得真的懂瞭些 science確實是很competitive的field 特彆是這些lab類的 發文章cycle還算快 就真的是分秒必爭 同事之間的閤作和競爭關係微妙 好奇如果有本從boston角度來講(vs. Berkeley)會是怎麼個態度 Isaacson很是細節之王 多少年前的事情 估計當事人都記不清楚瞭 他能寫細緻至極 feminism貫穿瞭整本書 最後幾章講gene editing moral的有點散
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