具體描述
The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.
When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.
Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.
The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.
Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?
After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species.
用戶評價
##很好的瞭解CRISP的科普
評分##讀瞭Emmanuelle Charpentier, Feng Zhang, &He jiankui, CRISPR, Gene editing historic records部分，作者寫到science內容一筆帶過，想瞭解詳細內容自己去看文獻，曆史的部分講述得比較精彩，不搞學術的人讀瞭能看到研究進步發展時間綫上科學傢們的主導、參與、被遺忘、被放棄及存活的真實展現，good read
評分##除瞭學習科學知識 還藉鑒得到成功科學傢的品質 追求卓越注重閤作然而又能嚴格管理自己的時間界限 生命科學的魅力 疫情初期緊鑼密鼓的研究與疫苗開發 意外還有1984 vs. Brave New World這一對比重現 雖然有主POV CRISPR學術之爭的敘述個人感覺尚且公正 希望能多收集一些行傢綫報實驗室風雲!
評分偵探小說一樣，好看的簡直停不下來，比前一步著作 達芬奇 好看的多，讀達芬奇的時候 一直瞌睡。這本書簡直停不下來。微積分的發現，大傢爭來爭去，DNA結構的發現，大傢爭來爭去，人類基因組計劃，大傢爭來爭去， crisper-cas9,大傢爭來爭去。其實你發現沒有，個人的貢獻是有限的，沒有誰，地球照樣轉。科學的發現和進步，是一個水到渠成，成韆上萬的人一步一步做齣來的，個人的貢獻往往被放大，而更多的人則被忽略。感覺Jennifer是一個很愛搶功勞的人，也許是中國人都zhangfeng有同情。不過她的閤作者都疏遠瞭她。雞血的中國媽媽可以看看，美國也有尖子班，張峰也上補習班的，不過他上的是將熒光蛋白重組錶達的相關工作。最不喜歡書裏麵的thought experiment, 是這本書最大的敗筆
評分##很精彩的故事，高尖端的科技，科學傢的爭名奪利，關於道德的爭論，都很有意思，不過感覺作者夾帶私貨略多
評分##"Great Inventions come from understanding basic science"
評分##真是一本一言難盡的書，有點不倫不類的。如果是個傳記，那麼這是我讀過的最失敗的傳記瞭，讀之前對女主充滿瞭崇拜，讀完瞭幾乎好感全無，覺得她好勝心過強。這本書是開始介紹珍妮弗·道德納的背景求學經曆以及如何開始研究RNA ，然後變成瞭一本CRISPR 科普，又陸續介紹瞭一群對CRISPR有貢獻的科學傢，然後開始八卦道德納和張的CRISPR 專利戰，然後又開始討論基因改造的道德性，然後聊瞭聊RNA和新冠，最後以得諾貝爾奬結束。其實與其寫成傳記，不如學成一部紀實文學，從各方麵客觀的去講述基因改造的發展更好一些。 讓我想八卦的地方是，作者至少在2019年就開始參加一些活動瞭，應該是在最遲2019就開始著手這本書，那麼後來的諾貝爾和新冠隻是巧閤的話，作者也太好運瞭。
評分##挺好看的，實效性很強，跟covid聯係很緊密。最喜歡看這種眾人拾柴火焰高，每個人的研究都為某個成功的發現奠定基石的故事。所以其實叫code breakers確實更閤適，很喜歡Doudna和Charpentier這種微妙的情感，既是閤作者又有點小競爭的感覺。中間有段講gene editing的好處和壞處覺得有點離題，好在後麵又拉迴來瞭
評分##roadtrip上聽完瞭有聲書 比預計的更有意思更drama crispr齣來的時候 很多報道podcast采訪 biotech/genes也hype很久瞭 但都知道瞭些皮毛 這本書聽完纔覺得真的懂瞭些 science確實是很competitive的field 特彆是這些lab類的 發文章cycle還算快 就真的是分秒必爭 同事之間的閤作和競爭關係微妙 好奇如果有本從boston角度來講(vs. Berkeley)會是怎麼個態度 Isaacson很是細節之王 多少年前的事情 估計當事人都記不清楚瞭 他能寫細緻至極 feminism貫穿瞭整本書 最後幾章講gene editing moral的有點散
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