具體描述
The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.
When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.
Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.
The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.
Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?
After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species.
用戶評價
##很精彩的故事，高尖端的科技，科學傢的爭名奪利，關於道德的爭論，都很有意思，不過感覺作者夾帶私貨略多
評分##真是一本一言難盡的書，有點不倫不類的。如果是個傳記，那麼這是我讀過的最失敗的傳記瞭，讀之前對女主充滿瞭崇拜，讀完瞭幾乎好感全無，覺得她好勝心過強。這本書是開始介紹珍妮弗·道德納的背景求學經曆以及如何開始研究RNA ，然後變成瞭一本CRISPR 科普，又陸續介紹瞭一群對CRISPR有貢獻的科學傢，然後開始八卦道德納和張的CRISPR 專利戰，然後又開始討論基因改造的道德性，然後聊瞭聊RNA和新冠，最後以得諾貝爾奬結束。其實與其寫成傳記，不如學成一部紀實文學，從各方麵客觀的去講述基因改造的發展更好一些。 讓我想八卦的地方是，作者至少在2019年就開始參加一些活動瞭，應該是在最遲2019就開始著手這本書，那麼後來的諾貝爾和新冠隻是巧閤的話，作者也太好運瞭。
評分##很精彩的故事，高尖端的科技，科學傢的爭名奪利，關於道德的爭論，都很有意思，不過感覺作者夾帶私貨略多
評分##作為對科技新聞有一定關注的讀者，我是覺得傳記大拿的這本新書略略有點水、有點散呀……可能書中紀事我多少有些瞭解，所以讀來新鮮感不強。而厚厚近600頁感覺有點四不像——既不是傳記、也不是新聞調查；有點像在翻資料匯編，又有點像在刷公眾號。 不過也不難看。最留下印象的幾點： ➊用生物學詞匯mosaic來形容人性的復雜多麵嚮，a better description than grayscale； ➋第一次瞭解到biohackers（書中以Josiah Zayner為代錶）這個群體。如何看待citizen science（民科）？ ➌作者引用Michael Sandel教授關於“playing god”的論述； ➍D與C兩位女科學傢漸行漸遠（不是鬧翻）的友誼（研究閤作與私交兩個層麵）。
評分##"Great Inventions come from understanding basic science"
評分##其實應該叫The Code Breakers，除瞭Doudna and Charpentier, 作者對Zhang Feng的評價也很高，作者一直在強調對於基礎科學研究的重要性，在十四五計劃也有強調，期待各國能加大科研投入for a greater good
評分##讀瞭Emmanuelle Charpentier, Feng Zhang, &He jiankui, CRISPR, Gene editing historic records部分，作者寫到science內容一筆帶過，想瞭解詳細內容自己去看文獻，曆史的部分講述得比較精彩，不搞學術的人讀瞭能看到研究進步發展時間綫上科學傢們的主導、參與、被遺忘、被放棄及存活的真實展現，good read
評分##A bit all over the place, but enligtening and informative. I'm learning things I didn't know and I thoroughly enjoyed the chapters where Issacson explored the ethical issues surrounding gene editing.
評分##科普的部分已經在其它書裏見過瞭，傳記的部分又不是很有意思。
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